Whether you are seeking treatment for depression and don't want to gain weight, or you want to consider using an antidepressant to help with weight loss. Learn about the challenge of weight gain when treating depression and which antidepressants may be best if you would also like to lose weight. Six medications you never knew could cause weight gain, and what to do if you currently take one of them. I have been taking 150mg of Seroquel once a day for the past 6 months and gained 30 pounds. The pounds were starting to pack up about 2 months ago. Everything You Need to Know About Antidepressants That Cause Weight Gain Answers Posted in: wellbutrin, depression, sleep disorders, bupropion Answer: it's unusual to gain weight on wellbutrin. it actually is a med Selective serotonin reuptake inhibitors (SSRIs) generally don't cause weight gain because the antidepressants boost serotonin, which helps you feel full. Get Health Facts Prescription Drugs Causing Weight Gain. Menopause, by definition, is the absence of menstrual periods for 12 consecutive months. The age of onset varies for each woman. Menopause symptoms include hot. Experts do not fully understand why antidepressants lead to weight gain in some people. One theory is that both metabolism and hunger levels may be affected. Prozac, or fluoxetine, is an antidepressant in a class known as selective serotonin reuptake inhibitors (SSRIs). Find out the top 6 scientificallyproven reasons why you're not losing weight and some simple, easy solutions to help with your weight loss. I gained no weight on Prozac and lost an interest In food. Weight didn't change by more than a couple pounds. I've been on an antidepressant for a few months and have gained more than 10 pounds. This is making me more depressed. Do all these drugs cause weight gain. weight loss, especially in underweight depressed or bulimic individuals, may be an unwanted effect of treatment with Prozac. About 2 percent of.