3 CONTRAINDICATIONS TRIMEBUTINE (trimebutine maleate) is contraindicated in patients with known hypersensitivity to trimebutine maleate or any of the excipients. Irritable bowel syndrome (IBS) is common in the general population and has a significant medical and socioeconomic impact. IBS has long been viewed as a functional. An international, peerreviewed, Open Access journal that spans the spectrum of drug design and development through to clinical applications. Page 1 of 5 NEW ZEALAND DATA SHEET COLOFAC 1. Product Name Colofac, 135 mg, Tablet. Qualitative and Quantitative Composition Each tablet contains 135 mg of. Colese Product Information 2 In in vitro studies mebeverine hydrochloride has been shown to have a papaverinelike spasmolytic effect on the smooth muscle of the. Mebeverine 135 mg FilmCoated tablets: Posology. Duration of use is not limited. If one or more doses are missed, the patient should continue with the next dose as. OMICS International publishes 700 Open Access Journals in the fields of Clinical, Medical, Life Science, Pharma, Environmental, Engineering and Management. Itopride (brand name Ganaton) is a prokinetic benzamide derivative unlike domperidone. These drugs inhibit dopamine and acetylcholine esterase enzyme and have a. There are no or limited amounts of data from the use of mebeverine in pregnant women. Animal studies are insufficient with respect to reproductive toxicity. Mebeverine is used to alleviate some of the symptoms of irritable bowel syndrome (IBS) and related conditions; specifically stomach pain and cramps.